In-silico and in-vitro toxicological evaluation of Tiktakam kashayam

“TIKTAKAM KASHAYAM” is evaluated by in-silico study using PASS online software. Its having anti-inflammatory activity and also anti-neoplastic especially colon cancer. In-vitro heavy metal analysis shows lead mercury below the detection limit, cadmium not detected arsenic present approved range. Some important toxicities like hepatotoxicity shown compound azadirachtin in Azadiracta indica, neurotoxic biflorne Inoldenlandia corymbosa, Ototoxicity sweroside, reproductive dysfunction produced luteolin Gentiana kuro. Neurotoxic kobusone, respiratory failure swertiamarin, ototoxicity sweroside plant swertia chirayata. Parkinsonism effect piperine pipperitin Piper longum. The ayurvedic formulation possess will be beneficial for treatment of inflammatory bowel disease.